Dual Inhibitors Targeting DNA and Histone Deacetylases
نویسندگان
چکیده
منابع مشابه
Dual Inhibitors Against Topoisomerases and Histone Deacetylases
Topoisomerases and histone deacetylases (HDACs) are considered as important therapeutic targets for a wide range of cancers, due to their association with the initiation, proliferation and survival of cancer cells. Topoisomerases are involved in the cleavage and religation processes of DNA, while HDACs regulate a dynamic epigenetic modification of the lysine amino acid on various proteins. Exte...
متن کاملHistone Deacetylases and their Inhibitors as Potential
treatment regimen is still an unmet need. This might lead to the fact that few CCA patients are suitable for the surgery as well as the limitation of other therapeutic modalities (Patel, 2006; Sia et al., 2013; Zabron et al., 2013). In addition, the palliative chemotherapy and radiotherapy have been used as adjuvant therapy for this cancer type. Various chemotherapeutic agents e.g. 5-fluorourac...
متن کاملTargeting histone deacetylases in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a dismal disease with a median survival below 6 months and a 5-year survival rate below 1%. Effective therapies for locally advanced or metastatic tumours are missing and curatively resected patients relapse in over 80% of the cases. Although histone deacetylases (HDACs) are involved in the control of proliferation, apoptosis, differentiation, migratio...
متن کاملDeveloping selective histone deacetylases (HDACs) inhibitors through ebselen and analogs
Histone deacetylases (HDACs) are key regulators of gene expression in cells and have been investigated as important therapeutic targets for cancer and other diseases. Different subtypes of HDACs appear to play disparate roles in the cells and are associated with specific diseases. Therefore, substantial effort has been made to develop subtype-selective HDAC inhibitors. In an effort to discover ...
متن کاملNovel Polyamine–Naphthalene Diimide Conjugates Targeting Histone Deacetylases and DNA for Cancer Phenotype Reprogramming
A series of hybrid compounds was designed to target histone deacetylases and ds-/G-quadruplex DNAs by merging structural features deriving from Scriptaid and compound 1. Compound 6 binds different DNA arrangements, inhibits HDACs both in vitro and in cells, and is able to induce a reduction of cell proliferation. Moreover, compound 6 displays cell phenotype-reprogramming properties since it pre...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pharmaceutical Fronts
سال: 2020
ISSN: 2628-5088,2628-5096
DOI: 10.1055/s-0040-1713873